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TDP-43在下丘脑的过表达驱动神经病理,导致小鼠代谢失调和行为障碍

TDP-43病理是肌萎缩性侧索硬化症(ALS)、额颞叶痴呆(FTD)和亨廷顿病(HD)等神经退行性疾病的关键特征。这些疾病共同表现出代谢和情绪失调,这可能与下丘脑的病理改变有关。在临床ALS患者的尸检中,发现下丘脑存在TDP-43包涵体,并且调控代谢和情绪的神经肽(食欲素/orexin、黑色素浓缩激素/MCH、催产素/oxytocin)表达神经元选择性缺失。

卵巢透明细胞癌中的早期病变

卵巢透明细胞癌并不常见,在卵巢上皮性恶性肿瘤中占比仅约12%,但却是第二常见的卵巢癌类型。该肿瘤大部分发生于子宫内膜异位症的情况下,常见于子宫内膜异位囊肿中。最近,英国病理医师Karunadhas等人在《Am J Surg Pathol》杂志报道了6例形态学和免疫组化都符合透明细胞癌、但仅累及子宫内膜异位囊肿的衬覆上皮而并无周围间质浸润的病例,并对这类“早期”透明细胞增生的病理报告提出了实用性建议。

Wild Boars (Sus scrofa, L. 1758) from Castile and Leon Region (Spain): A Histopathology Survey

This study aims to report and interpret some histopathological findings (from the lung, liver, and kidney) in wild boars from different areas of Castile and León (Spain) to evaluate the health status of this population. Parasitic pneumonia (34.7%) in the lungs and cellular alterations (33.3%) in the liver are some of the most common and relevant lesions found.

Feasibility study of single-image super-resolution scanning system based on deep learning for pathological diagnosis of oral epithelial dysplasia

This study aimed to evaluate the feasibility of applying deep learning combined with a super-resolution scanner for the digital scanning and diagnosis of oral epithelial dysplasia (OED) slides using Dakewe DS30R digital scanner.

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